{"id":67818,"date":"2026-08-24T08:00:00","date_gmt":"2026-08-24T01:00:00","guid":{"rendered":"https:\/\/thaipropertynews.com\/feeds\/?p=67818"},"modified":"2026-08-24T08:00:00","modified_gmt":"2026-08-24T01:00:00","slug":"antengene-announces-2026-interim-results-achieves-first-ever-profitability-and-accelerates-value-creation-through-innovative-rd","status":"publish","type":"post","link":"https:\/\/thaipropertynews.com\/feeds\/?p=67818","title":{"rendered":"Antengene Announces 2026 Interim Results: Achieves First\u2011Ever Profitability and Accelerates Value Creation Through Innovative R&D"},"content":{"rendered":"\n\n\n
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SHANGHAI and HONG KONG<\/span>, Aug. 24, 2026<\/span> \/PRNewswire\/ — Antengene Corporation Limited (“Antengene”<\/b>, SEHK: 6996.HK), a leading innovative, commercial-stage global biotech company dedicated to discovering, developing and commercializing first-in-class and\/or best-in-class medicines for autoimmune diseases, solid tumors and hematological malignancies, today provided an overview of its interim results for the period ended June 30, 2026, which were announced on August 21, 2026, together with recent business highlights and strategic progress.<\/b><\/p>\n

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Dr. Jay Mei, Antengene’s Founder, Chairman, and CEO,<\/b> said, “In H1 2026, Antengene achieved its first\u2011ever profitability, with total revenue of RMB 513 million, representing a year\u2011on\u2011year increase of 864.5%, and profit for the period of RMB 216 million. <\/b>This is an important validation of our strategy to create value through internal innovation and global partnerships. The successful execution of our partnering strategy is translating the strength of our pipeline into meaningful financial returns. Most notably, our global exclusive license agreement with UCB <\/b>for ATG\u2011201 (CD19 x CD3 T\u2011cell engager [TCE])<\/b> generated a USD 60 million upfront payment. We also entered into an exclusive license agreement with K2 Therapeutics, established by MPM BioImpact,<\/b> for ATG\u2011106 (first\u2011in\u2011class CDH6 x CD3 TCE)<\/b>, under which the aggregate upfront and near\u2011term consideration amounts to approximately USD 20 million. Together with potential milestone payments and tiered royalties from these partnerships, as well as commercial revenue from XPOVIO\u00ae<\/sup>, these revenue streams further strengthen our financial position and expand our capacity to invest in innovation.<\/b><\/p>\n

Our late-stage clinical program ATG\u2011022 (CLDN18.2 antibody\u2011drug conjugate [ADC]) <\/b>has received CDE Breakthrough Therapy Designation, demonstrating strong efficacy and best-in-class safety in gastric cancer across all levels of CLDN18.2 expression, as well as in other CLDN18.2+ solid tumors. We are advancing two key clinical studies in gastric cancer: the CLINCH\u20112 study, evaluating ATG\u2011022 in combination with chemotherapy and an anti\u2011PD\u20111 antibody in the 1L treatment of patients with gastric or gastroesophageal junction adenocarcinoma (GC\/GEJC) with CLDN18.2 IHC 1+ \u2265 1%; and the pivotal Phase\u202fIII CLINCH\u20113 study evaluating ATG-022 monotherapy for GC\/GEJC patients with CLDN18.2 IHC 2+ \u2265 20%. We are confident in the potential of ATG-022 to benefit a broad population of patients with CLDN18.2-expressing tumors and believe it is well positioned to become a cornerstone of our pipeline and one of our most important future value drivers.<\/b><\/p>\n

In TCE innovation, we continue to expand our capabilities beyond our established AnTenGager\u00ae<\/sup> TCE platform<\/b>. We have successfully developed and newly launched TriGager\u2122<\/sup>, our next generation logic-gated tri-specific TCE platform, together with new TCE formats incorporating costimulatory moieties<\/b>, further broadening our comprehensive TCE engineering toolbox. We are also deepening the integration of AI across our R&D engine.<\/b> By linking multi-omics analysis with internally generated protein datasets, our AI platform identifies novel targets and target combinations, informs molecular design, and optimizes antibody developability.<\/b> The platform has already contributed to the nomination of ATG-115, a T-cell engager (TCE) for hepatocellular carcinoma (HCC) directed at a novel, AI-identified tumor-associated antigen. AI-enabled combinatorial screening has also surfaced multiple novel target pairs now advancing toward future TriGager\u2122<\/sup> programs.<\/b> Combined with the differentiated engineering of our AnTenGager\u00ae<\/sup> and TriGager\u2122 <\/sup>platforms, AI expands the range of molecules we can design for diseases of high unmet medical need.<\/p>\n

Beyond these programs, we are advancing the next wave of internally generated innovation. ATG-125, our B7-H3 x PD-L1 bispecific ADC,<\/b> has demonstrated encouraging preclinical efficacy, with an IND submission planned for Q1 2027. ATG-207, our first-in-class \u03b1CD3-TGF-\u03b2 bifunctional fusion protein,<\/b> represents a differentiated approach to restoring immune tolerance in T cell-mediated autoimmune disease. ATG\u2011112, our first\u2011in\u2011class ALPPL2 \u00d7 CD3 TCE, <\/b>targets gynecological tumors, digestive system malignancies, bladder cancer and NSCLC. ATG\u2011110, our LY6G6D \u00d7 CD3 TCE, <\/b>targets IO\u2011resistant microsatellite\u2011stable colorectal cancer. Together, these programs highlight the breadth of our innovation and represent potential future value drivers across oncology and autoimmune diseases.<\/b><\/p>\n

As Antengene enters its next stage of development, we will continue to strengthen our R&D capabilities, advance our clinical pipeline and deepen global partnerships. With sustained innovation and a stronger financial position, we are well positioned to execute our strategy and create long\u2011term value.”<\/b><\/p>\n

\u3010Business Updates\u3011<\/b><\/p>\n

1.ATG-022\uff08CLDN18.2 ADC\uff09<\/b><\/p>\n