{"id":64767,"date":"2026-07-15T17:00:00","date_gmt":"2026-07-15T10:00:00","guid":{"rendered":"https:\/\/thaipropertynews.com\/feeds\/?p=64767"},"modified":"2026-07-15T17:00:00","modified_gmt":"2026-07-15T10:00:00","slug":"ascletis-selects-for-clinical-development-a-fixed-dose-combination-of-first-in-class-oral-small-molecule-gipr-agonist-asc48-and-oral-small-molecule-glp-1r-agonist-asc30","status":"publish","type":"post","link":"https:\/\/thaipropertynews.com\/feeds\/?p=64767","title":{"rendered":"Ascletis Selects for Clinical Development a Fixed-Dose Combination of First-in-Class Oral Small Molecule GIPR Agonist, ASC48, and Oral Small Molecule GLP-1R Agonist, ASC30"},"content":{"rendered":"\n\n\n
\"\"<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

– ASC48 is a potentially first-in-class oral small molecule GIPR agonist.<\/i><\/p>\n

– ASC48 demonstrated an EC<\/i>50<\/sub><\/i> of 1 pM in the hGIPR cAMP activation assay, exhibiting greater potency than tirzepatide (EC<\/i>50<\/sub><\/i> = 3 pM) and is a selective agonist for GIPR without activity for GLP-1R and GCGR.<\/i><\/p>\n

– ASC48 demonstrated excellent oral bioavailability and drug exposure as well as long half-life in rodents and non-human primates (NHPs), supporting once-daily oral dosing in humans.<\/i><\/p>\n

– Fixed dose combination of ASC30 and ASC48 (ASC30_48 FDC) is a potentially first-in-class oral one-pill, once-daily treatment for obesity, targeting both GLP-1R and GIPR.<\/i><\/p>\n

–<\/i> ASC30_48 FDC demonstrated approximately 52% greater relative body weight reduction compared to ASC30 monotherapy in a head-to-head NHP study.<\/i><\/p>\n

– ASC30_48 FDC is a once-daily oral small molecule with the same mechanism of action as tirzepatide, the market leading GLP\/GIP once weekly subcutaneous peptide with over $30 billion in sales in 2025. <\/i><\/p>\n

– Submission of an Investigational New Drug Application (IND) to the U.S. Food and Drug Administration (FDA) for ASC30_48 FDC oral tablets is expected in the fourth quarter of 2026.<\/i><\/p>\n

HONG KONG<\/span>, July 15, 2026<\/span> \/PRNewswire\/ — Ascletis Pharma Inc. (HKEX: 1672, “Ascletis”) announces that it has selected a fixed-dose combination of ASC48, a potentially first-in-class oral small molecule GIPR agonist, and ASC30, an oral small molecule GLP-1R agonist, for clinical development. ASC30 and ASC48 fixed-dose combination (ASC30_48 FDC) is a potentially first-in-class oral one-pill, once-daily therapy for obesity, targeting GLP-1R and GIPR.<\/p>\n

\n<\/div>\n

ASC48 was discovered in-house utilizing Ascletis’ Artificial Intelligence-assisted Structure-Based Drug Discovery (AISBDD) technology. In a head-to-head study, ASC48 demonstrated an EC50 <\/sub>of 1 pM in the hGIPR cAMP activation assay, exhibiting greater potency than tirzepatide (EC50<\/sub> = 3 pM) and is a selective agonist for GIPR without activity for GLP-1R and GCGR. ASC48 demonstrated excellent oral bioavailability and drug exposure as well as long half-life in rodents and non-human primates (NHPs), supporting once-daily oral dosing in humans.<\/p>\n

ASC30_48 FDC demonstrated approximately 52% greater relative body weight reduction compared to ASC30 monotherapy in a head-to-head NHP study (Table 1).<\/p>\n

Table 1. Once-daily oral administration of ASC30_48 FDC for eight consecutive days produced 52% and 518% greater relative body weight reduction, respectively compared to ASC30 and ASC48 monotherapies<\/p>\n

\n\n\n\n\n\n\n
\n

Group<\/span><\/p>\n<\/td>\n

\n

Dosing<\/span><\/p>\n<\/td>\n

\n

Total body
weight change
from baseline<\/span><\/p>\n<\/td>\n

\n

Greater relative body\u00a0weight reduction versus
ASC30 monotherapy or
ASC48 monotherapy<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

ASC30 (GLP-1R agonist)<\/span><\/p>\n<\/td>\n

\n

2 mg\/kg
PO,\u00a0QD<\/span><\/p>\n<\/td>\n

\n

-6.9\u00a0%<\/span><\/p>\n<\/td>\n

\n

NA<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

ASC48 (GIPR agonist)<\/span><\/p>\n<\/td>\n

\n

5 mg\/kg
PO,\u00a0QD<\/span><\/p>\n<\/td>\n

\n

-1.7\u00a0%<\/span><\/p>\n<\/td>\n

\n

NA<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

ASC30_48 FDC (GLP-
1R\/GIPR agonist)<\/span><\/p>\n<\/td>\n

\n

2 mg\/kg ASC30
and\u00a0
5 mg\/kg ASC48<\/span><\/p>\n

PO, QD<\/span><\/p>\n<\/td>\n

\n

-10.5\u00a0%<\/span><\/p>\n<\/td>\n

\n

52%<\/span><\/p>\n

(vs ASC30 monotherapy)<\/span><\/p>\n

518%
(vs ASC48\u00a0monotherapy)<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n

Notes: <\/i><\/p>\n

PO: oral administration; QD: once daily.<\/p>\n

Submission of an Investigational New Drug Application (IND) to the U.S. Food and Drug Administration (FDA) for ASC30_48 FDC oral tablets is expected in the fourth quarter of 2026.<\/p>\n

“We look forward to initiating this trial to evaluate the fixed-dose combination of ASC48 and ASC30 with the aim of developing a first-in-class oral treatment regimen to potentially improve outcomes for people with obesity,” said Jinzi Jason Wu, Ph.D., Founder, Chairman and CEO of Ascletis. “We believe there is an unmet medical need for an oral drug that when given in combination with GLP-1R therapy can achieve the same weight loss and tolerability as tirzepatide weekly injections.”<\/p>\n

About Ascletis Pharma Inc.<\/b><\/p>\n

Ascletis Pharma Inc. is a fully integrated biotechnology company focused on the development and commercialization of potentially best-in-class and first-in-class therapeutics to treat metabolic diseases. Utilizing its proprietary Artificial Intelligence-assisted Structure-Based Drug Discovery (AISBDD) and Ultra-Long-Acting Platform (ULAP) technologies as well as Peptide Oral Transport ENhancement Technology (POTENT), Ascletis has developed multiple drug candidates in-house, including both small molecules and peptides, such as its lead program, ASC30, a small molecule GLP-1R agonist designed to be administered once daily orally and once monthly to once quarterly subcutaneously as a treatment therapy and a maintenance therapy for chronic weight management; ASC36, an amylin receptor peptide agonist, ASC35, a once-monthly subcutaneously administered GLP-1R\/GIPR dual peptide agonist and ASC37, a GLP-1R\/GIPR\/GCGR triple peptide agonist, ASC39, an eloralintide-like potent and amylin-selective oral small molecule amylin receptor agonist, ASC30_39 FDC, a fixed-dose combination (FDC) of ASC30 (GLP-1 RA) and ASC39 (amylin RA), ASC30_48 FDC, a fixed-dose combination (FDC) of ASC30 (GLP-1 RA) and ASC48 (GIP RA),for chronic weight management. Ascletis is listed on the Hong Kong Stock Exchange (1672.HK).<\/p>\n

For more information, please visit www.ascletis.com<\/a>.\u00a0<\/p>\n

Contact\uff1a<\/p>\n

Peter Vozzo
ICR Healthcare
443-231-0505 (U.S.)
Peter.vozzo@icrhealthcare.com<\/a>\u00a0<\/p>\n

Ascletis Pharma Inc. PR and IR Teams
+86-181-0650-9129 (China)
pr@ascletis.com<\/a>
ir@ascletis.com<\/a>\u00a0<\/p>","protected":false},"excerpt":{"rendered":"

<\/p>\n\n\n\n
\"\"<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

– ASC48 is a potentially first-in-class oral small molecule GIPR agonist.<\/i><\/p>\n

– ASC48 demonstrated an EC<\/i>50<\/sub><\/i> of 1 pM in the hGIPR cAMP activation assay, exhibiting greater potency than tirzepatide (EC<\/i>50<\/sub><\/i> = 3 pM) and is a selective agonist for GIPR without activity for GLP-1R and GCGR.<\/i><\/p>\n

– ASC48 demonstrated excellent oral bioavailability and drug exposure as well as long half-life in rodents and non-human primates (NHPs), supporting once-daily oral dosing in humans.<\/i><\/p>\n

– Fixed dose combination of ASC30 and ASC48 (ASC30_48 FDC) is a potentially first-in-class oral one-pill, once-daily treatment for obesity, targeting both GLP-1R and GIPR.<\/i><\/p>\n

–<\/i> ASC30_48 FDC demonstrated approximately 52% greater relative body weight reduction compared to ASC30 monotherapy in a head-to-head NHP study.<\/i><\/p>\n

– ASC30_48 FDC is a once-daily oral small molecule with the same mechanism of action as tirzepatide, the market leading GLP\/GIP once weekly subcutaneous peptide with over $30 billion in sales in 2025. <\/i><\/p>\n

– Submission of an Investigational New Drug Application (IND) to the U.S. Food and Drug Administration (FDA) for ASC30_48 FDC oral tablets is expected in the fourth quarter of 2026.<\/i><\/p>\n

HONG KONG<\/span>, July 15, 2026<\/span> \/PRNewswire\/ — Ascletis Pharma Inc. (HKEX: 1672, “Ascletis”) announces that it has selected a fixed-dose combination of ASC48, a potentially first-in-class oral small molecule GIPR agonist, and ASC30, an oral small molecule GLP-1R agonist, for clinical development. ASC30 and ASC48 fixed-dose combination (ASC30_48 FDC) is a potentially first-in-class oral one-pill, once-daily therapy for obesity, targeting GLP-1R and GIPR.<\/p>\n

\n<\/div>\n

ASC48 was discovered in-house utilizing Ascletis’ Artificial Intelligence-assisted Structure-Based Drug Discovery (AISBDD) technology. In a head-to-head study, ASC48 demonstrated an EC50 <\/sub>of 1 pM in the hGIPR cAMP activation assay, exhibiting greater potency than tirzepatide (EC50<\/sub> = 3 pM) and is a selective agonist for GIPR without activity for GLP-1R and GCGR. ASC48 demonstrated excellent oral bioavailability and drug exposure as well as long half-life in rodents and non-human primates (NHPs), supporting once-daily oral dosing in humans.<\/p>\n

ASC30_48 FDC demonstrated approximately 52% greater relative body weight reduction compared to ASC30 monotherapy in a head-to-head NHP study (Table 1).<\/p>\n

Table 1. Once-daily oral administration of ASC30_48 FDC for eight consecutive days produced 52% and 518% greater relative body weight reduction, respectively compared to ASC30 and ASC48 monotherapies<\/p>\n

\n\n\n\n\n\n\n
\n

Group<\/span><\/p>\n<\/td>\n

\n

Dosing<\/span><\/p>\n<\/td>\n

\n

Total body
weight change
from baseline<\/span><\/p>\n<\/td>\n

\n

Greater relative body\u00a0weight reduction versus
ASC30 monotherapy or
ASC48 monotherapy<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

ASC30 (GLP-1R agonist)<\/span><\/p>\n<\/td>\n

\n

2 mg\/kg
PO,\u00a0QD<\/span><\/p>\n<\/td>\n

\n

-6.9\u00a0%<\/span><\/p>\n<\/td>\n

\n

NA<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

ASC48 (GIPR agonist)<\/span><\/p>\n<\/td>\n

\n

5 mg\/kg
PO,\u00a0QD<\/span><\/p>\n<\/td>\n

\n

-1.7\u00a0%<\/span><\/p>\n<\/td>\n

\n

NA<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

ASC30_48 FDC (GLP-
1R\/GIPR agonist)<\/span><\/p>\n<\/td>\n

\n

2 mg\/kg ASC30
and\u00a0
5 mg\/kg ASC48<\/span><\/p>\n

PO, QD<\/span><\/p>\n<\/td>\n

\n

-10.5\u00a0%<\/span><\/p>\n<\/td>\n

\n

52%<\/span><\/p>\n

(vs ASC30 monotherapy)<\/span><\/p>\n

518%
(vs ASC48\u00a0monotherapy)<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

Notes: <\/i><\/p>\n

PO: oral administration; QD: once daily.<\/p>\n

Submission of an Investigational New Drug Application (IND) to the U.S. Food and Drug Administration (FDA) for ASC30_48 FDC oral tablets is expected in the fourth quarter of 2026.<\/p>\n

“We look forward to initiating this trial to evaluate the fixed-dose combination of ASC48 and ASC30 with the aim of developing a first-in-class oral treatment regimen to potentially improve outcomes for people with obesity,” said Jinzi Jason Wu, Ph.D., Founder, Chairman and CEO of Ascletis. “We believe there is an unmet medical need for an oral drug that when given in combination with GLP-1R therapy can achieve the same weight loss and tolerability as tirzepatide weekly injections.”<\/p>\n

About Ascletis Pharma Inc.<\/b><\/p>\n

Ascletis Pharma Inc. is a fully integrated biotechnology company focused on the development and commercialization of potentially best-in-class and first-in-class therapeutics to treat metabolic diseases. Utilizing its proprietary Artificial Intelligence-assisted Structure-Based Drug Discovery (AISBDD) and Ultra-Long-Acting Platform (ULAP) technologies as well as Peptide Oral Transport ENhancement Technology (POTENT), Ascletis has developed multiple drug candidates in-house, including both small molecules and peptides, such as its lead program, ASC30, a small molecule GLP-1R agonist designed to be administered once daily orally and once monthly to once quarterly subcutaneously as a treatment therapy and a maintenance therapy for chronic weight management; ASC36, an amylin receptor peptide agonist, ASC35, a once-monthly subcutaneously administered GLP-1R\/GIPR dual peptide agonist and ASC37, a GLP-1R\/GIPR\/GCGR triple peptide agonist, ASC39, an eloralintide-like potent and amylin-selective oral small molecule amylin receptor agonist, ASC30_39 FDC, a fixed-dose combination (FDC) of ASC30 (GLP-1 RA) and ASC39 (amylin RA), ASC30_48 FDC, a fixed-dose combination (FDC) of ASC30 (GLP-1 RA) and ASC48 (GIP RA),for chronic weight management. Ascletis is listed on the Hong Kong Stock Exchange (1672.HK).<\/p>\n

For more information, please visit www.ascletis.com<\/a>.\u00a0<\/p>\n

Contact\uff1a<\/p>\n

Peter Vozzo
ICR Healthcare
443-231-0505 (U.S.)
Peter.vozzo@icrhealthcare.com<\/a>\u00a0<\/p>\n

Ascletis Pharma Inc. PR and IR Teams
+86-181-0650-9129 (China)
pr@ascletis.com<\/a>
ir@ascletis.com<\/a>\u00a0<\/p>\n

<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"rop_custom_images_group":[],"rop_custom_messages_group":[],"rop_publish_now":"initial","rop_publish_now_accounts":[],"rop_publish_now_history":[],"rop_publish_now_status":"pending","footnotes":""},"categories":[5,7],"tags":[],"class_list":["post-64767","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cision-pr-newswire","category-cision-pr-newswire-en"],"_links":{"self":[{"href":"https:\/\/thaipropertynews.com\/feeds\/index.php?rest_route=\/wp\/v2\/posts\/64767","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/thaipropertynews.com\/feeds\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/thaipropertynews.com\/feeds\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/thaipropertynews.com\/feeds\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/thaipropertynews.com\/feeds\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=64767"}],"version-history":[{"count":0,"href":"https:\/\/thaipropertynews.com\/feeds\/index.php?rest_route=\/wp\/v2\/posts\/64767\/revisions"}],"wp:attachment":[{"href":"https:\/\/thaipropertynews.com\/feeds\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=64767"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/thaipropertynews.com\/feeds\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=64767"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/thaipropertynews.com\/feeds\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=64767"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}