{"id":49121,"date":"2026-02-26T15:15:00","date_gmt":"2026-02-26T08:15:00","guid":{"rendered":"https:\/\/thaipropertynews.com\/feeds\/?p=49121"},"modified":"2026-02-26T15:15:00","modified_gmt":"2026-02-26T08:15:00","slug":"genoway-revolutionizing-the-prediction-of-antibody-therapies-in-humans-with-unique-mouse-model","status":"publish","type":"post","link":"https:\/\/thaipropertynews.com\/feeds\/?p=49121","title":{"rendered":"genOway: Revolutionizing the Prediction of Antibody Therapies in Humans with Unique Mouse Model"},"content":{"rendered":"\n\n\n
\"\"<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

LYON, France<\/span>, Feb. 26, 2026<\/span> \/PRNewswire\/ — Antibody therapies are changing the treatment of cancer, inflammatory diseases and infections. However, many promising drug candidates fail in clinical trials. A study in Science Immunology shows that genOway’s genO-hFc\u03b3R mouse model enables more accurate prediction of therapeutic antibody efficacy and safety.<\/p>\n

\"genOway:<\/a>
genOway: Revolutionizing the Prediction of Antibody Therapies in Humans with Unique Mouse Model<\/span> <\/div>\n

Why Antibody Therapies Fail in Late-Stage Testing<\/b><\/p>\n

Antibody therapies work in part by binding to Fc\u03b3 receptors, proteins found on immune cells that control key immune functions such as antibody-mediated cell killing and inflammation. Since these receptors are different between species, human therapies tested in standard laboratory mice give unreliable efficacy results or miss potential safety risks. These discrepancies cause expensive late-stage failures and slow patient access to new therapies.<\/p>\n

A New Mouse Model with Humanized Fc\u03b3 Receptors Set to Become a Gamechanger<\/b><\/p>\n

A new study published in Science Immunology showed that an innovative mouse model developed by genOway, genO-hFc\u03b3R, helps scientists better predict the efficacy and safety of therapeutic antibodies in humans. The model allows scientists to rank different antibody candidates by how they are likely to perform, measure how effectively they target specific immune cells, and evaluate their potential to slow disease progression. This gives researchers key early insights to guide decisions and accelerate drug development.<\/p>\n

Video on genO-hFc\u03b3R mice: https:\/\/www.youtube.com\/watch?v=H7xO-xGJV8Q<\/a><\/p>\n

Read the publication: https:\/\/www.science.org\/doi\/10.1126\/sciimmunol.ady7328<\/a><\/p>\n

A Complex Scientific Challenge Achieved Through International Collaboration<\/b><\/p>\n

Due to the species-specific nature of Fc\u03b3 receptors, developing this model demanded multidisciplinary expertise in mouse genetics, antibody biology, and human immunology.<\/p>\n

The achievement was made possible through an international consortium of leading biopharmaceutical partners, led by genOway, who combined their knowledge to co-develop and co-validate the genO-hFc\u03b3R mouse model. Consortium members included genOway (France), a company specializing in developing highly predictive preclinical models; argenx (Belgium), a pioneer in Fc-engineering and FcRn biology; Innate Pharma (France), a leader in natural killer cell-based immunotherapies; and Vir Biotechnology (USA), focused on the development of immunotherapies; among other members.\u00a0The group collaborated with VIB-Ghent University (Belgium), a leading immunology institute, to publish the study in Science Immunology. In this study, scientists at VIB-Ghent University mapped Fc receptor expression and regulation\u00a0to illustrate how the new mouse model could be used to better model human disease and coordinated\u00a0the publication of the work.<\/p>\n

A Unique Solution Available for the Scientific Community<\/b><\/p>\n

The genO\u2013hFc\u03b3R model builds on a previous mouse model developed in 2008 by genOway and its scientific partners, in which multiple Fc\u03b3R genes were humanized. Since its launch to the scientific community in 2024, genO-hFc\u03b3R has been adopted to advance preclinical programs of biopharmaceutical companies and nonprofit organizations, including the Gates Foundation, as one of the foundation’s global health research initiatives.<\/p>\n

Read the Gates Foundation press release at https:\/\/www.genoway.com\/news-events\/genoway-gates-foundation-2025<\/a><\/u><\/p>\n

About genOway
<\/b>genOway\u00a0is a biotechnology company that provides highly predictive preclinical models and solutions to biopharmaceutical companies, CROs\u00a0and academic institutions to bridge the gap between preclinical findings and clinical success. More information at genoway.com<\/i>.<\/p>\n

Contact
<\/b>Ana\u00a0REZA\u00a0
Marketing Communications Manager
reza@genoway.com<\/a>\u00a0\u00a0<\/p>\n

\u00a0<\/p>\n

\"genOway:<\/a>
genOway: Revolutionizing the Prediction of Antibody Therapies in Humans with Unique Mouse Model<\/span> <\/div>\n

\u00a0<\/p>","protected":false},"excerpt":{"rendered":"

<\/p>\n\n\n\n
\"\"<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

LYON, France<\/span>, Feb. 26, 2026<\/span> \/PRNewswire\/ — Antibody therapies are changing the treatment of cancer, inflammatory diseases and infections. However, many promising drug candidates fail in clinical trials. A study in Science Immunology shows that genOway’s genO-hFc\u03b3R mouse model enables more accurate prediction of therapeutic antibody efficacy and safety.<\/p>\n

\"genOway:<\/a>
genOway: Revolutionizing the Prediction of Antibody Therapies in Humans with Unique Mouse Model<\/span> <\/div>\n

Why Antibody Therapies Fail in Late-Stage Testing<\/b><\/p>\n

Antibody therapies work in part by binding to Fc\u03b3 receptors, proteins found on immune cells that control key immune functions such as antibody-mediated cell killing and inflammation. Since these receptors are different between species, human therapies tested in standard laboratory mice give unreliable efficacy results or miss potential safety risks. These discrepancies cause expensive late-stage failures and slow patient access to new therapies.<\/p>\n

A New Mouse Model with Humanized Fc\u03b3 Receptors Set to Become a Gamechanger<\/b><\/p>\n

A new study published in Science Immunology showed that an innovative mouse model developed by genOway, genO-hFc\u03b3R, helps scientists better predict the efficacy and safety of therapeutic antibodies in humans. The model allows scientists to rank different antibody candidates by how they are likely to perform, measure how effectively they target specific immune cells, and evaluate their potential to slow disease progression. This gives researchers key early insights to guide decisions and accelerate drug development.<\/p>\n

Video on genO-hFc\u03b3R mice: https:\/\/www.youtube.com\/watch?v=H7xO-xGJV8Q<\/a><\/p>\n

Read the publication: https:\/\/www.science.org\/doi\/10.1126\/sciimmunol.ady7328<\/a><\/p>\n

A Complex Scientific Challenge Achieved Through International Collaboration<\/b><\/p>\n

Due to the species-specific nature of Fc\u03b3 receptors, developing this model demanded multidisciplinary expertise in mouse genetics, antibody biology, and human immunology.<\/p>\n

The achievement was made possible through an international consortium of leading biopharmaceutical partners, led by genOway, who combined their knowledge to co-develop and co-validate the genO-hFc\u03b3R mouse model. Consortium members included genOway (France), a company specializing in developing highly predictive preclinical models; argenx (Belgium), a pioneer in Fc-engineering and FcRn biology; Innate Pharma (France), a leader in natural killer cell-based immunotherapies; and Vir Biotechnology (USA), focused on the development of immunotherapies; among other members.\u00a0The group collaborated with VIB-Ghent University (Belgium), a leading immunology institute, to publish the study in Science Immunology. In this study, scientists at VIB-Ghent University mapped Fc receptor expression and regulation\u00a0to illustrate how the new mouse model could be used to better model human disease and coordinated\u00a0the publication of the work.<\/p>\n

A Unique Solution Available for the Scientific Community<\/b><\/p>\n

The genO\u2013hFc\u03b3R model builds on a previous mouse model developed in 2008 by genOway and its scientific partners, in which multiple Fc\u03b3R genes were humanized. Since its launch to the scientific community in 2024, genO-hFc\u03b3R has been adopted to advance preclinical programs of biopharmaceutical companies and nonprofit organizations, including the Gates Foundation, as one of the foundation’s global health research initiatives.<\/p>\n

Read the Gates Foundation press release at https:\/\/www.genoway.com\/news-events\/genoway-gates-foundation-2025<\/a><\/u><\/p>\n

About genOway
<\/b>genOway\u00a0is a biotechnology company that provides highly predictive preclinical models and solutions to biopharmaceutical companies, CROs\u00a0and academic institutions to bridge the gap between preclinical findings and clinical success. More information at genoway.com<\/i>.<\/p>\n

Contact
<\/b>Ana\u00a0REZA\u00a0
Marketing Communications Manager
reza@genoway.com<\/a>\u00a0\u00a0<\/p>\n

\u00a0<\/p>\n

\"genOway:<\/a>
genOway: Revolutionizing the Prediction of Antibody Therapies in Humans with Unique Mouse Model<\/span> <\/div>\n

\u00a0<\/p>\n

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