{"id":46762,"date":"2026-01-29T20:00:00","date_gmt":"2026-01-29T13:00:00","guid":{"rendered":"https:\/\/thaipropertynews.com\/feeds\/?p=46762"},"modified":"2026-01-29T20:00:00","modified_gmt":"2026-01-29T13:00:00","slug":"xtalpi-convenes-global-experts-to-shape-the-future-of-molecular-glue-drug-discovery-from-serendipity-to-precision","status":"publish","type":"post","link":"https:\/\/thaipropertynews.com\/feeds\/?p=46762","title":{"rendered":"XtalPi Convenes Global Experts to Shape the Future of Molecular Glue Drug Discovery: From Serendipity to Precision"},"content":{"rendered":"<table border=\"0\" cellspacing=\"10\" cellpadding=\"5\" align=\"right\">\n<tbody>\n<tr>\n<td><img decoding=\"async\" src=\"https:\/\/mma.prnasia.com\/media2\/2872576\/logo____RGB_02_Logo.jpg?p=medium600\" border=\"0\" alt=\"\" title=\"logo\" hspace=\"0\" vspace=\"0\" width=\"118\" \/><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul type=\"disc\">\n<li>Global thought leaders presented cutting-edge research at the 2026 International Symposium on Molecular Glue Drug Discovery<span>.<\/span><\/li>\n<li>XtalPi unveils the AI-driven XGlue\u2122 platform to enable rapid, closed-loop molecular glue drug discovery.<\/li>\n<li>Cross-sector discussions emphasized the need for bridging gaps between academic research, industrial development, and clinical applications.<\/li>\n<\/ul>\n<p><span class=\"legendSpanClass\"><span class=\"xn-location\">SHANGHAI<\/span><\/span>, <span class=\"legendSpanClass\"><span class=\"xn-chron\">Jan. 29, 2026<\/span><\/span> \/PRNewswire\/ &#8212; Recently,\u00a0XtalPi, a global leader in AI- and robotics-powered drug discovery, successfully concluded its <b>2026 International Symposium on Molecular Glue Drug Discovery<\/b>. The event convened leading scientists, biopharma innovators, entrepreneurs, and investors from around the world to explore how emerging technologies are redefining strategies for historically &#8220;undruggable&#8221; protein targets.<\/p>\n<div class=\"PRN_ImbeddedAssetReference\">\n<p><a href=\"https:\/\/mma.prnasia.com\/media2\/2872562\/XtalPi_successfully_concluded_2026_International_Symposium_Molecular_Glue_Drug_Discovery.html\" target=\"_blank\" rel=\"nofollow\"><img decoding=\"async\" src=\"https:\/\/mma.prnasia.com\/media2\/2872562\/XtalPi_successfully_concluded_2026_International_Symposium_Molecular_Glue_Drug_Discovery.jpg?p=medium600\" title=\"XtalPi successfully concluded its 2026 International Symposium on Molecular Glue Drug Discovery\" alt=\"XtalPi successfully concluded its 2026 International Symposium on Molecular Glue Drug Discovery\" \/><\/a><br \/><span>XtalPi successfully concluded its 2026 International Symposium on Molecular Glue Drug Discovery<\/span><\/p>\n<\/div>\n<p>Molecular glue discovery has long relied on serendipity. In his opening remarks, XtalPi Co-founder and CEO <b>Dr. <span class=\"xn-person\">Jian Ma<\/span><\/b> emphasized the need for a fundamental paradigm shift\u2014moving from chance-based discoveries toward a systematic, technology-driven approach enabled by AI, robotics, and global collaboration.<\/p>\n<p>Anchoring this transition, XtalPi Vice President <b>Dr. <span class=\"xn-person\">Yang Xie<\/span><\/b> introduced the company&#8217;s proprietary <b>XGlue\u2122 platform<\/b>. XGlue\u2122 integrates physics-based AI modeling to interrogate complex protein\u2013protein interactions with an agentic AI\u2013controlled autonomous synthesis workflow. This closed-loop <i>design\u2013make\u2013test<\/i> system enables rapid iteration and significantly expands the addressable target space for molecular glue therapeutics, positioning XtalPi at the forefront of next-generation protein degradation.<\/p>\n<p>The symposium featured a series of scientific presentations highlighting the evolution of the field. <b>Prof. <span class=\"xn-person\">Nathanael S. Gray<\/span><\/b> (<span class=\"xn-org\">Stanford University<\/span>) and <b>Prof. <span class=\"xn-person\">Bruno Correia<\/span><\/b> (EPFL) discussed leveraging chemically induced proximity and computational de novo design to uncover functional interactions beyond the reach of traditional drug discovery. <b>Prof. <span class=\"xn-person\">Ke Ding<\/span><\/b> (Chinese Academy of Sciences) and <b>Dr. <span class=\"xn-person\">Yong Cang<\/span><\/b> (ShanghaiTech University) presented compelling examples of rationally discovered and designed molecular glues addressing critical diseases with significant unmet medical need. <b>Dr. <span class=\"xn-person\">Jianwei Che<\/span><\/b> (Dana-Farber Cancer Institute) and <b>Dr. <span class=\"xn-person\">Liqiang Fu<\/span><\/b> (GluBio) further highlighted how AI-driven methodologies and enabling technologies are improving target selectivity, enhancing molecular potency, and strengthening the safety profile of glue-based therapeutics. From an investment and commercialization perspective, <b>Mr. <span class=\"xn-person\">Peter Zhang<\/span><\/b> (YAFO Capital) outlined strategic pathways for scaling molecular glue therapies across global markets.<\/p>\n<p>The symposium concluded with a cross-sector roundtable on building a sustainable innovation ecosystem for protein degradation. Moderated by <b>Dr. <span class=\"xn-person\">Yang Xie<\/span><\/b>, the discussion brought together leaders from <b>Sanofi, Betta Pharma, GluBio<\/b>, and other organizations to address the critical gaps between academic discovery, industrial development, and clinical translation. A shared consensus emerged: sustained progress in protein degradation will require deep integration across science, industry, and capital.<\/p>\n<p>As molecular glue therapeutics continue to gain momentum, the convergence of predictive AI and high-throughput automation is accelerating a shift toward logic-driven drug discovery\u2014transforming once-intractable biological targets into viable therapeutic opportunities.<\/p>\n<p><b>About XtalPi<\/b><\/p>\n<p>XtalPi Holdings Limited (XtalPi, 2228.HK) was founded in 2015 by three physicists from the <span class=\"xn-org\">Massachusetts Institute of Technology<\/span> (<span class=\"xn-org\">MIT<\/span>). It is an innovative R&amp;D platform powered by quantum physics, artificial intelligence, and robotics. By integrating first-principles calculations, AI algorithms, high-performance cloud computing, and standardized automation systems, XtalPi provides digital and intelligent R&amp;D solutions for companies in the pharmaceutical, materials science, agricultural technology, energy, new chemicals, and cosmetics industries.<\/p>\n<div class=\"PRN_ImbeddedAssetReference\">\n<\/div>","protected":false},"excerpt":{"rendered":"<p><!-- wp:html --><\/p>\n<table border=\"0\" cellspacing=\"10\" cellpadding=\"5\" align=\"right\">\n<tbody>\n<tr>\n<td><img decoding=\"async\" src=\"https:\/\/mma.prnasia.com\/media2\/2872576\/logo____RGB_02_Logo.jpg?p=medium600\" border=\"0\" alt=\"\" title=\"logo\" hspace=\"0\" vspace=\"0\" width=\"118\" \/><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul type=\"disc\">\n<li>Global thought leaders presented cutting-edge research at the 2026 International Symposium on Molecular Glue Drug Discovery<span>.<\/span><\/li>\n<li>XtalPi unveils the AI-driven XGlue\u2122 platform to enable rapid, closed-loop molecular glue drug discovery.<\/li>\n<li>Cross-sector discussions emphasized the need for bridging gaps between academic research, industrial development, and clinical applications.<\/li>\n<\/ul>\n<p><span class=\"legendSpanClass\"><span class=\"xn-location\">SHANGHAI<\/span><\/span>, <span class=\"legendSpanClass\"><span class=\"xn-chron\">Jan. 29, 2026<\/span><\/span> \/PRNewswire\/ &#8212; Recently,\u00a0XtalPi, a global leader in AI- and robotics-powered drug discovery, successfully concluded its <b>2026 International Symposium on Molecular Glue Drug Discovery<\/b>. The event convened leading scientists, biopharma innovators, entrepreneurs, and investors from around the world to explore how emerging technologies are redefining strategies for historically &#8220;undruggable&#8221; protein targets.<\/p>\n<div class=\"PRN_ImbeddedAssetReference\">\n<p><a href=\"https:\/\/mma.prnasia.com\/media2\/2872562\/XtalPi_successfully_concluded_2026_International_Symposium_Molecular_Glue_Drug_Discovery.html\" target=\"_blank\" rel=\"nofollow\"><img decoding=\"async\" src=\"https:\/\/mma.prnasia.com\/media2\/2872562\/XtalPi_successfully_concluded_2026_International_Symposium_Molecular_Glue_Drug_Discovery.jpg?p=medium600\" title=\"XtalPi successfully concluded its 2026 International Symposium on Molecular Glue Drug Discovery\" alt=\"XtalPi successfully concluded its 2026 International Symposium on Molecular Glue Drug Discovery\" \/><\/a><br \/><span>XtalPi successfully concluded its 2026 International Symposium on Molecular Glue Drug Discovery<\/span><\/p>\n<\/div>\n<p>Molecular glue discovery has long relied on serendipity. In his opening remarks, XtalPi Co-founder and CEO <b>Dr. <span class=\"xn-person\">Jian Ma<\/span><\/b> emphasized the need for a fundamental paradigm shift\u2014moving from chance-based discoveries toward a systematic, technology-driven approach enabled by AI, robotics, and global collaboration.<\/p>\n<p>Anchoring this transition, XtalPi Vice President <b>Dr. <span class=\"xn-person\">Yang Xie<\/span><\/b> introduced the company&#8217;s proprietary <b>XGlue\u2122 platform<\/b>. XGlue\u2122 integrates physics-based AI modeling to interrogate complex protein\u2013protein interactions with an agentic AI\u2013controlled autonomous synthesis workflow. This closed-loop <i>design\u2013make\u2013test<\/i> system enables rapid iteration and significantly expands the addressable target space for molecular glue therapeutics, positioning XtalPi at the forefront of next-generation protein degradation.<\/p>\n<p>The symposium featured a series of scientific presentations highlighting the evolution of the field. <b>Prof. <span class=\"xn-person\">Nathanael S. Gray<\/span><\/b> (<span class=\"xn-org\">Stanford University<\/span>) and <b>Prof. <span class=\"xn-person\">Bruno Correia<\/span><\/b> (EPFL) discussed leveraging chemically induced proximity and computational de novo design to uncover functional interactions beyond the reach of traditional drug discovery. <b>Prof. <span class=\"xn-person\">Ke Ding<\/span><\/b> (Chinese Academy of Sciences) and <b>Dr. <span class=\"xn-person\">Yong Cang<\/span><\/b> (ShanghaiTech University) presented compelling examples of rationally discovered and designed molecular glues addressing critical diseases with significant unmet medical need. <b>Dr. <span class=\"xn-person\">Jianwei Che<\/span><\/b> (Dana-Farber Cancer Institute) and <b>Dr. <span class=\"xn-person\">Liqiang Fu<\/span><\/b> (GluBio) further highlighted how AI-driven methodologies and enabling technologies are improving target selectivity, enhancing molecular potency, and strengthening the safety profile of glue-based therapeutics. From an investment and commercialization perspective, <b>Mr. <span class=\"xn-person\">Peter Zhang<\/span><\/b> (YAFO Capital) outlined strategic pathways for scaling molecular glue therapies across global markets.<\/p>\n<p>The symposium concluded with a cross-sector roundtable on building a sustainable innovation ecosystem for protein degradation. Moderated by <b>Dr. <span class=\"xn-person\">Yang Xie<\/span><\/b>, the discussion brought together leaders from <b>Sanofi, Betta Pharma, GluBio<\/b>, and other organizations to address the critical gaps between academic discovery, industrial development, and clinical translation. A shared consensus emerged: sustained progress in protein degradation will require deep integration across science, industry, and capital.<\/p>\n<p>As molecular glue therapeutics continue to gain momentum, the convergence of predictive AI and high-throughput automation is accelerating a shift toward logic-driven drug discovery\u2014transforming once-intractable biological targets into viable therapeutic opportunities.<\/p>\n<p><b>About XtalPi<\/b><\/p>\n<p>XtalPi Holdings Limited (XtalPi, 2228.HK) was founded in 2015 by three physicists from the <span class=\"xn-org\">Massachusetts Institute of Technology<\/span> (<span class=\"xn-org\">MIT<\/span>). It is an innovative R&amp;D platform powered by quantum physics, artificial intelligence, and robotics. By integrating first-principles calculations, AI algorithms, high-performance cloud computing, and standardized automation systems, XtalPi provides digital and intelligent R&amp;D solutions for companies in the pharmaceutical, materials science, agricultural technology, energy, new chemicals, and cosmetics industries.<\/p>\n<div class=\"PRN_ImbeddedAssetReference\">\n<\/div>\n<p><!-- \/wp:html --><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"rop_custom_images_group":[],"rop_custom_messages_group":[],"rop_publish_now":"initial","rop_publish_now_accounts":[],"rop_publish_now_history":[],"rop_publish_now_status":"pending","footnotes":""},"categories":[1],"tags":[],"class_list":["post-46762","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/thaipropertynews.com\/feeds\/index.php?rest_route=\/wp\/v2\/posts\/46762","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/thaipropertynews.com\/feeds\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/thaipropertynews.com\/feeds\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/thaipropertynews.com\/feeds\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/thaipropertynews.com\/feeds\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=46762"}],"version-history":[{"count":0,"href":"https:\/\/thaipropertynews.com\/feeds\/index.php?rest_route=\/wp\/v2\/posts\/46762\/revisions"}],"wp:attachment":[{"href":"https:\/\/thaipropertynews.com\/feeds\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=46762"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/thaipropertynews.com\/feeds\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=46762"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/thaipropertynews.com\/feeds\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=46762"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}