{"id":23280,"date":"2025-05-13T16:45:28","date_gmt":"2025-05-13T09:45:28","guid":{"rendered":"https:\/\/thaipropertynews.com\/feeds\/?p=23280"},"modified":"2025-05-13T16:45:28","modified_gmt":"2025-05-13T09:45:28","slug":"abbisko-therapeutics-to-present-updated-results-from-the-phase-2-study-of-irpagratinib-in-combination-with-atezolizumab-for-the-treatment-of-advanced-hepatocellular-carcinoma-at-the-2025-esmo-gi-congr","status":"publish","type":"post","link":"https:\/\/thaipropertynews.com\/feeds\/?p=23280","title":{"rendered":"Abbisko Therapeutics to Present Updated Results from the Phase 2 Study of Irpagratinib in Combination with Atezolizumab for the Treatment of Advanced Hepatocellular Carcinoma at the 2025 ESMO GI Congress"},"content":{"rendered":"

SHANGHAI<\/span><\/span>, May 13, 2025<\/span><\/span> \/PRNewswire\/ — Abbisko Therapeutics Co., Ltd. (02256.HK) today announced that updated results from the phase 2 study of irpagratinib (ABSK011) in combination with atezolizumab for the treatment of advanced hepatocellular carcinoma (HCC) will be presented at the 2025 ESMO GI Congress, taking place in Barcelona, Spain<\/span> from July 2 to July 5<\/span>. The oral presentation will highlight the regimen’s favorable safety and promising anti-tumor activity in both treatment-naive and previously treated FGF19+ HCC patients. The evident objective response rate (ORR) and progression free survival (PFS) benefit underscores the potential of irpagratinib-based combinations in the treatment of HCC.<\/p>\n

Event Details:<\/b><\/p>\n

Session:<\/b>\u00a0Mini Oral session – Innovation in GI cancers
Presentation Format: <\/b>Oral Presentation<\/p>\n

Title: <\/b>Irpagratinib (ABSK-011) plus Atezolizumab in First-line (1L) and Immune Checkpoint Inhibitors (ICIs) Treated Advanced Hepatocellular Carcinoma (HCC) with FGF19 Overexpression (+): Updated Results of the Phase 2 ABSK-011-201 Study<\/b><\/p>\n

Presentation number<\/b>\uff1a<\/b>149MO<\/p>\n

Presenter: <\/b>Qi Cheng
Date and Time: <\/b>\u00a0Beijing Time 2Jul2025 23:15-23:20
\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 Local time 2Jul2025 17:15-17:20<\/p>\n

About Irpagratinib (ABSK-011)<\/b><\/p>\n

Irpagratinib is a highly-selective FGFR4 small molecule inhibitor designed to target overexpression of the FGF19 signaling pathway. Several epidemiological studies indicate that approximately 30% of HCC patients worldwide exhibit FGF19 overexpression. Development of targeted therapies against FGFR4 represent an innovative and novel approach to the treatment of HCC.<\/p>\n

To date, no FGFR4 inhibitor has been granted regulatory approval globally. According to Frost & Sullivan, irpagratinib is expected to become the first breakthrough treatment for the treatment of aHCC patients with FGF19 overexpression.<\/p>\n

In addition to monotherapy, Abbisko Therapeutics is exploring irpagratinib in combination with atezolizumab, an anti-PD-L1 antibody manufactured by F. Hoffmann-La Roche and Roche (China<\/span>), in a Phase II study. At the previous 2024 ESMO GI Congress, Abbisko presented clinical data demonstrating 220mg irpagratinib BID in combination with atezolizumab achieved a 50% objective response rate (ORR) in FGF19+ HCC patients who had previously received immune checkpoint inhibition therapy.<\/p>","protected":false},"excerpt":{"rendered":"

<\/p>\n

SHANGHAI<\/span><\/span>, May 13, 2025<\/span><\/span> \/PRNewswire\/ — Abbisko Therapeutics Co., Ltd. (02256.HK) today announced that updated results from the phase 2 study of irpagratinib (ABSK011) in combination with atezolizumab for the treatment of advanced hepatocellular carcinoma (HCC) will be presented at the 2025 ESMO GI Congress, taking place in Barcelona, Spain<\/span> from July 2 to July 5<\/span>. The oral presentation will highlight the regimen’s favorable safety and promising anti-tumor activity in both treatment-naive and previously treated FGF19+ HCC patients. The evident objective response rate (ORR) and progression free survival (PFS) benefit underscores the potential of irpagratinib-based combinations in the treatment of HCC.<\/p>\n

Event Details:<\/b><\/p>\n

Session:<\/b>\u00a0Mini Oral session – Innovation in GI cancers
Presentation Format: <\/b>Oral Presentation<\/p>\n

Title: <\/b>Irpagratinib (ABSK-011) plus Atezolizumab in First-line (1L) and Immune Checkpoint Inhibitors (ICIs) Treated Advanced Hepatocellular Carcinoma (HCC) with FGF19 Overexpression (+): Updated Results of the Phase 2 ABSK-011-201 Study<\/b><\/p>\n

Presentation number<\/b>\uff1a<\/b>149MO<\/p>\n

Presenter: <\/b>Qi Cheng
Date and Time: <\/b>\u00a0Beijing Time 2Jul2025 23:15-23:20
\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 Local time 2Jul2025 17:15-17:20<\/p>\n

About Irpagratinib (ABSK-011)<\/b><\/p>\n

Irpagratinib is a highly-selective FGFR4 small molecule inhibitor designed to target overexpression of the FGF19 signaling pathway. Several epidemiological studies indicate that approximately 30% of HCC patients worldwide exhibit FGF19 overexpression. Development of targeted therapies against FGFR4 represent an innovative and novel approach to the treatment of HCC.<\/p>\n

To date, no FGFR4 inhibitor has been granted regulatory approval globally. According to Frost & Sullivan, irpagratinib is expected to become the first breakthrough treatment for the treatment of aHCC patients with FGF19 overexpression.<\/p>\n

In addition to monotherapy, Abbisko Therapeutics is exploring irpagratinib in combination with atezolizumab, an anti-PD-L1 antibody manufactured by F. Hoffmann-La Roche and Roche (China<\/span>), in a Phase II study. At the previous 2024 ESMO GI Congress, Abbisko presented clinical data demonstrating 220mg irpagratinib BID in combination with atezolizumab achieved a 50% objective response rate (ORR) in FGF19+ HCC patients who had previously received immune checkpoint inhibition therapy.<\/p>\n

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