{"id":14853,"date":"2024-12-12T11:19:17","date_gmt":"2024-12-12T04:19:17","guid":{"rendered":"https:\/\/thaipropertynews.com\/feeds\/?p=14853"},"modified":"2024-12-12T11:19:17","modified_gmt":"2024-12-12T04:19:17","slug":"laekna-announces-poster-presentation-on-internally-discovered-selective-pi3k%ce%b1-inhibitor-at-sabcs-2024","status":"publish","type":"post","link":"https:\/\/thaipropertynews.com\/feeds\/?p=14853","title":{"rendered":"Laekna Announces Poster Presentation on Internally Discovered Selective PI3K\u03b1 Inhibitor at SABCS 2024"},"content":{"rendered":"

LOS\u00a0ANGELES<\/span>, Dec. 12, 2024<\/span><\/span> \/PRNewswire\/ — Laekna (2105.HK) today announced that the company will present an internally discovered preclinical candidate at the 2024 San Antonio Breast Cancer Symposium (SABCS) on December 13, 2024<\/span>. The presentation will feature preclinical characterization of LAE118, a novel allosteric pan-mutant selective PI3K\u03b1 inhibitor.<\/p>\n

“We appreciate this recognition of our expertise and strength in pre-clinical developments of novel drugs”, said Dr. Justin Gu<\/span>, Chief Scientific Officer of Laekna. “The development of LAE118 was led by Dr. Ming Li<\/span>, with collaborative contributions from the Med Chem, Biology and AIDD (AI-driven Drug Discovery) teams of Laekna. We have significantly accelerated the development of our preclinical drug candidate with cutting-edge artificial intelligence tools”.<\/p>\n

\u00a0“As a novel allosteric inhibitor, LAE118 demonstrates excellent potency and selectivity towards various PI3K\u03b1 mutants. With superior efficacy and higher tolerability than its competitors in animal models, LAE118 has great potential to become the best-in-class pan-mutant-selective PI3K\u03b1 inhibitor. We look forward to bringing this novel therapy to the patients”, said Dr. Justin Gu<\/span>.<\/p>\n

PI3K\u03b1 mutations are prevalent in patients with breast, colorectal, lung, endometrial, and numerous other cancers. Targeting PI3K\u03b1 in cancer has been validated as a therapeutic strategy, as evidenced by the approved drugs. However, the first-generation drugs inhibit the wild-type PI3K\u03b1 with equal potency, which raises concerns of tolerability and therapeutic efficacy. Therefore, there is a pressing need to develop novel PI3K\u03b1-targeted therapies that can minimize on-target toxicities and overcome drug resistance.<\/p>\n

While making significant progress in pre-clinical developments of drug candidates in cancer, Laekna has also established a comprehensive Activin-ActRII portfolio in metabolism. Following the clinical collaboration with Eli Lilly on LAE102 (ActRIIA selective antibody), Laekna has progressedLAE103, an ActRIIB selective inhibitor and LAE123, a dual inhibitor against ActRIIA\/IIB, into IND-enabling studies, aiming to advance them to the clinical stage swiftly.<\/p>\n

The San Antonio Breast Cancer Symposium is an annual event cosponsored by the AACR and UT Health San Antonio’s Mays Cancer Center. The meeting is the largest and most prestigious scientific gathering on breast cancer research.<\/p>\n

Presentation details are as follows:<\/b><\/p>\n

Abstract Number:<\/b>\u00a0SESS-3548<\/p>\n

Poster Number:<\/b>\u00a0P5-06-16\u00a0<\/p>\n

Title:<\/b>\u00a0Preclinical characterization of LAE118, a novel allosteric pan-mutant selective PI3K\u03b1 inhibitor<\/p>\n

Authors: <\/b>Ming Li<\/span>, Ruipeng Zhang<\/span>, Junyan Chen<\/span>, Meijuan Hu<\/span>, Xiaofen Lin<\/span>, Minhua Zhang<\/span>, Xiang-Ju Justin Gu<\/span><\/p>\n

Time:<\/b>\u00a0Friday, Dec. 13, 2024, 12:30 p.m.<\/span> \u2013 14:00 p.m.\u00a0 CST<\/p>\n

Location:<\/b>\u00a0Halls 2-3, Henry B. Gonzalez\u00a0Convention Center, San Antonio, Texas<\/span><\/p>\n

Abstract Highlights:<\/b><\/p>\n

LAE118 is a novel allosteric pan-mutant selective PI3K\u03b1 inhibitor. LAE118 demonstrates excellent in vitro anti-proliferation activities in PI3K\u03b1 mutant cell lines and remains active against cells resistant to orthosteric PI3K\u03b1 inhibitors. LAE118 shows strong anti-tumor growth effect in Xenograft models at a dose that is much lower than other allosteric inhibitors and has less effect on glucose homeostasis compared to orthosteric PI3K\u03b1 inhibitors. In pre-clinical toxicology studies, LAE118 also demonstrated good tolerability. These data indicate that LAE118 offers improved efficacy and larger safety window. LAE118 is currently in IND enabling stage and Laekna aims to submit the IND application at the earliest opportunity.<\/p>\n

About Laekna <\/b><\/p>\n

Stock Code: 2105.HK<\/p>\n

Founded in 2016, Laekna is a science-driven, clinical-stage biotechnology company committed to bringing novel therapeutics to\u00a0patients with cancer, metabolic diseases and liver fibrosis patients around the world.<\/p>\n

As of June 30, 2024<\/span>, Laekna has initiated seven\u00a0clinical trials for LAE102, LAE002(afuresertib), LAE001 and LAE005 to address unmet medical needs\u00a0in obesity and cancers.<\/p>\n

LAE102 is our internally discovered antibody against ActRIIA.\u00a0It has been shown in the pre-clinical studies to increase lean mass and decrease fat mass. We’ve obtained IND approvals\u00a0from the FDA\u00a0and the CDE for LAE102 in obesity indication and are advancing the Phase I clinical trial in China<\/span>.<\/p>\n

Blocking Activin-ActRII pathway could promote muscle regeneration and decrease fat mass. Laekna team has accumulated tremendous experiences\u00a0and deep know-how in this specific field and is developing more drug candidates (LAE103\u00a0and LAE123), in addition to LAE102,\u00a0to maximize the value of targeting ActRII receptors.\u00a0<\/p>\n

In the cancer area, Laekna has built a comprehensive portfolio of drug candidates, covering the treatment of breast cancer, prostate cancer, ovarian cancer and PD-1\/ PD-L1 drug-resistant solid tumors. LAE002\u00a0(afuresertib) is a potent AKT inhibitor that inhibits all three AKT isoforms (AKT1, AKT2 and AKT3) as well as one of the only two AKT inhibitors in late-stage development for breast and prostate cancer globally. Laekna has commenced the Phase III clinical trial (AFFIRM-205)\u00a0for LAE002 in patients with HR+\/HER2- breast cancer.<\/p>\n

Laekna, Inc. (2105.HK)\u00a0was listed on the Main Board of The Stock Exchange of Hong Kong Limited (the “Hong Kong Stock Exchange”) on June 29<\/span>, 2023.\u00a0<\/p>\n

For more information, please visit: https:\/\/www.laekna.com\/<\/a> <\/u>\u00a0or https:\/\/www.linkedin.com\/company\/74110713\/<\/a><\/u><\/p>\n

Forward-Looking Statements<\/b><\/p>\n

This press release may contain certain “forward-looking statements” which are not historical facts, but instead are predictions about future events based on Laekna’s current beliefs, assumptions and expectations, commonly identified by words such as “would”, “may”, “expects”, “believes”, “plans”, “intends”, “projects” and other terms with similar meaning. Although we believe that our predictions are reasonable, future events are inherently uncertain and our actual future results or performance may be materially different from what we expect. Accordingly, you are strongly cautioned that reliance on any forward-looking statements is subject to significant known and unknown risks and uncertainties. All forward-looking statements contained herein are qualified by reference to the cautionary statements set forth in this section. All information provided in this press release is as of the date of this press release and are based on assumptions that we believe to be reasonable as of this date, and we do not undertake any obligation to update any forward-looking statement, except as required under applicable law.<\/p>","protected":false},"excerpt":{"rendered":"

<\/p>\n

LOS\u00a0ANGELES<\/span>, Dec. 12, 2024<\/span><\/span> \/PRNewswire\/ — Laekna (2105.HK) today announced that the company will present an internally discovered preclinical candidate at the 2024 San Antonio Breast Cancer Symposium (SABCS) on December 13, 2024<\/span>. The presentation will feature preclinical characterization of LAE118, a novel allosteric pan-mutant selective PI3K\u03b1 inhibitor.<\/p>\n

“We appreciate this recognition of our expertise and strength in pre-clinical developments of novel drugs”, said Dr. Justin Gu<\/span>, Chief Scientific Officer of Laekna. “The development of LAE118 was led by Dr. Ming Li<\/span>, with collaborative contributions from the Med Chem, Biology and AIDD (AI-driven Drug Discovery) teams of Laekna. We have significantly accelerated the development of our preclinical drug candidate with cutting-edge artificial intelligence tools”.<\/p>\n

\u00a0“As a novel allosteric inhibitor, LAE118 demonstrates excellent potency and selectivity towards various PI3K\u03b1 mutants. With superior efficacy and higher tolerability than its competitors in animal models, LAE118 has great potential to become the best-in-class pan-mutant-selective PI3K\u03b1 inhibitor. We look forward to bringing this novel therapy to the patients”, said Dr. Justin Gu<\/span>.<\/p>\n

PI3K\u03b1 mutations are prevalent in patients with breast, colorectal, lung, endometrial, and numerous other cancers. Targeting PI3K\u03b1 in cancer has been validated as a therapeutic strategy, as evidenced by the approved drugs. However, the first-generation drugs inhibit the wild-type PI3K\u03b1 with equal potency, which raises concerns of tolerability and therapeutic efficacy. Therefore, there is a pressing need to develop novel PI3K\u03b1-targeted therapies that can minimize on-target toxicities and overcome drug resistance.<\/p>\n

While making significant progress in pre-clinical developments of drug candidates in cancer, Laekna has also established a comprehensive Activin-ActRII portfolio in metabolism. Following the clinical collaboration with Eli Lilly on LAE102 (ActRIIA selective antibody), Laekna has progressedLAE103, an ActRIIB selective inhibitor and LAE123, a dual inhibitor against ActRIIA\/IIB, into IND-enabling studies, aiming to advance them to the clinical stage swiftly.<\/p>\n

The San Antonio Breast Cancer Symposium is an annual event cosponsored by the AACR and UT Health San Antonio’s Mays Cancer Center. The meeting is the largest and most prestigious scientific gathering on breast cancer research.<\/p>\n

Presentation details are as follows:<\/b><\/p>\n

Abstract Number:<\/b>\u00a0SESS-3548<\/p>\n

Poster Number:<\/b>\u00a0P5-06-16\u00a0<\/p>\n

Title:<\/b>\u00a0Preclinical characterization of LAE118, a novel allosteric pan-mutant selective PI3K\u03b1 inhibitor<\/p>\n

Authors: <\/b>Ming Li<\/span>, Ruipeng Zhang<\/span>, Junyan Chen<\/span>, Meijuan Hu<\/span>, Xiaofen Lin<\/span>, Minhua Zhang<\/span>, Xiang-Ju Justin Gu<\/span><\/p>\n

Time:<\/b>\u00a0Friday, Dec. 13, 2024, 12:30 p.m.<\/span> \u2013 14:00 p.m.\u00a0 CST<\/p>\n

Location:<\/b>\u00a0Halls 2-3, Henry B. Gonzalez\u00a0Convention Center, San Antonio, Texas<\/span><\/p>\n

Abstract Highlights:<\/b><\/p>\n

LAE118 is a novel allosteric pan-mutant selective PI3K\u03b1 inhibitor. LAE118 demonstrates excellent in vitro anti-proliferation activities in PI3K\u03b1 mutant cell lines and remains active against cells resistant to orthosteric PI3K\u03b1 inhibitors. LAE118 shows strong anti-tumor growth effect in Xenograft models at a dose that is much lower than other allosteric inhibitors and has less effect on glucose homeostasis compared to orthosteric PI3K\u03b1 inhibitors. In pre-clinical toxicology studies, LAE118 also demonstrated good tolerability. These data indicate that LAE118 offers improved efficacy and larger safety window. LAE118 is currently in IND enabling stage and Laekna aims to submit the IND application at the earliest opportunity.<\/p>\n

About Laekna <\/b><\/p>\n

Stock Code: 2105.HK<\/p>\n

Founded in 2016, Laekna is a science-driven, clinical-stage biotechnology company committed to bringing novel therapeutics to\u00a0patients with cancer, metabolic diseases and liver fibrosis patients around the world.<\/p>\n

As of June 30, 2024<\/span>, Laekna has initiated seven\u00a0clinical trials for LAE102, LAE002(afuresertib), LAE001 and LAE005 to address unmet medical needs\u00a0in obesity and cancers.<\/p>\n

LAE102 is our internally discovered antibody against ActRIIA.\u00a0It has been shown in the pre-clinical studies to increase lean mass and decrease fat mass. We’ve obtained IND approvals\u00a0from the FDA\u00a0and the CDE for LAE102 in obesity indication and are advancing the Phase I clinical trial in China<\/span>.<\/p>\n

Blocking Activin-ActRII pathway could promote muscle regeneration and decrease fat mass. Laekna team has accumulated tremendous experiences\u00a0and deep know-how in this specific field and is developing more drug candidates (LAE103\u00a0and LAE123), in addition to LAE102,\u00a0to maximize the value of targeting ActRII receptors.\u00a0<\/p>\n

In the cancer area, Laekna has built a comprehensive portfolio of drug candidates, covering the treatment of breast cancer, prostate cancer, ovarian cancer and PD-1\/ PD-L1 drug-resistant solid tumors. LAE002\u00a0(afuresertib) is a potent AKT inhibitor that inhibits all three AKT isoforms (AKT1, AKT2 and AKT3) as well as one of the only two AKT inhibitors in late-stage development for breast and prostate cancer globally. Laekna has commenced the Phase III clinical trial (AFFIRM-205)\u00a0for LAE002 in patients with HR+\/HER2- breast cancer.<\/p>\n

Laekna, Inc. (2105.HK)\u00a0was listed on the Main Board of The Stock Exchange of Hong Kong Limited (the “Hong Kong Stock Exchange”) on June 29<\/span>, 2023.\u00a0<\/p>\n

For more information, please visit: https:\/\/www.laekna.com\/<\/a> <\/u>\u00a0or https:\/\/www.linkedin.com\/company\/74110713\/<\/a><\/u><\/p>\n

Forward-Looking Statements<\/b><\/p>\n

This press release may contain certain “forward-looking statements” which are not historical facts, but instead are predictions about future events based on Laekna’s current beliefs, assumptions and expectations, commonly identified by words such as “would”, “may”, “expects”, “believes”, “plans”, “intends”, “projects” and other terms with similar meaning. Although we believe that our predictions are reasonable, future events are inherently uncertain and our actual future results or performance may be materially different from what we expect. Accordingly, you are strongly cautioned that reliance on any forward-looking statements is subject to significant known and unknown risks and uncertainties. All forward-looking statements contained herein are qualified by reference to the cautionary statements set forth in this section. All information provided in this press release is as of the date of this press release and are based on assumptions that we believe to be reasonable as of this date, and we do not undertake any obligation to update any forward-looking statement, except as required under applicable law.<\/p>\n

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