\u2013 D-2570 demonstrates robust efficacy and favorable safety profile, achieving skin clearance comparable to leading biologics \u2013<\/p>\n
SHANGHAI<\/span><\/span>, Dec. 3, 2024<\/span><\/span> \/PRNewswire\/ —\u00a0InventisBio Co., Ltd. today announced promising results from a Phase 2 clinical trial of D-2570, an oral selective inhibitor of the TYK2 kinase, in patients with moderate to severe plaque psoriasis. The randomized, multicenter, double-blind, placebo-controlled study demonstrated that D-2570 achieved significant efficacy in improving skin clearance while maintaining a favorable safety profile.<\/p>\n Key Findings:<\/p>\n \u226585% of patients treated with D-2570 in all three dose groups achieved PASI 75 (75% or greater improvement in the Psoriasis Area and Severity Index) by week 12, compared to 12.5% in placebo group.<\/p>\n 50% of patients receiving the high dose of D-2570 achieved PASI 100 (complete skin clearance) by week 12, compared to 2.5% in placebo group.<\/p>\n PASI 90 and sPGA 0\/1 responses also significantly favored D-2570 over placebo, with 77.5% and 87.5%, respectively, in the high-dose group, versus 5.0% and 20%, respectively, in placebo group.<\/p>\n The trial enrolled 161 patients randomized to three dose levels of D-2570 or placebo. The primary endpoint of PASI 75 was achieved by a significantly greater proportion of patients in all D-2570 dose groups compared to placebo (p<0.001). Superior efficacy was observed across secondary endpoints, including PASI 90, PASI 100, and static Physician’s Global Assessment (sPGA) 0\/1.<\/p>\n Safety Profile:<\/p>\n D-2570 was well-tolerated, with no serious adverse events reported. The majority of adverse events were mild to moderate (CTCAE Grade 1 or 2), and no new safety signals were identified. The safety profile was consistent with other TYK2 inhibitors that are approved or currently in clinical development.<\/p>\n “Moderate to severe plaque psoriasis remains a significant burden for patients, affecting their physical health and quality of life. D-2570 has demonstrated a transformative potential with efficacy approaching that of biologics and IL-23 targeted peptide therapies, while offering the convenience of oral administration,” said Dr. Ling Zhang<\/span>, Chief Medical Officer of InventisBio. “We are committed to advancing the development of D-2570 to bring innovative and effective treatment options to patients living with autoimmune diseases such as psoriasis and inflammatory bowel diseases.”<\/p>\n The complete data from this Phase 2 trial will be presented at upcoming scientific conferences.<\/p>\n About D-2570:<\/p>\n D-2570 is an oral TYK2 JH2 pseudokinase domain inhibitor under development for the treatment of autoimmune diseases, including psoriasis. By selectively targeting TYK2, D-2570 modulates key cytokine signaling pathways involved in autoimmune inflammation, offering a potential alternative to biologic therapies.<\/p>\n About InventisBio:<\/p>\n InventisBio Co., Ltd. is a clinical-stage biotech company dedicated to discovering and developing innovative small-molecule therapies for the treatment of cancer, metabolic and autoimmune diseases. By leveraging a strong research pipeline and a focus on unmet medical needs, InventisBio strives to deliver transformative treatments to patients worldwide.<\/p>","protected":false},"excerpt":{"rendered":" <\/p>\n \u2013 D-2570 demonstrates robust efficacy and favorable safety profile, achieving skin clearance comparable to leading biologics \u2013<\/p>\n SHANGHAI<\/span><\/span>, Dec. 3, 2024<\/span><\/span> \/PRNewswire\/ —\u00a0InventisBio Co., Ltd. today announced promising results from a Phase 2 clinical trial of D-2570, an oral selective inhibitor of the TYK2 kinase, in patients with moderate to severe plaque psoriasis. The randomized, multicenter, double-blind, placebo-controlled study demonstrated that D-2570 achieved significant efficacy in improving skin clearance while maintaining a favorable safety profile.<\/p>\n Key Findings:<\/p>\n \u226585% of patients treated with D-2570 in all three dose groups achieved PASI 75 (75% or greater improvement in the Psoriasis Area and Severity Index) by week 12, compared to 12.5% in placebo group.<\/p>\n 50% of patients receiving the high dose of D-2570 achieved PASI 100 (complete skin clearance) by week 12, compared to 2.5% in placebo group.<\/p>\n PASI 90 and sPGA 0\/1 responses also significantly favored D-2570 over placebo, with 77.5% and 87.5%, respectively, in the high-dose group, versus 5.0% and 20%, respectively, in placebo group.<\/p>\n The trial enrolled 161 patients randomized to three dose levels of D-2570 or placebo. The primary endpoint of PASI 75 was achieved by a significantly greater proportion of patients in all D-2570 dose groups compared to placebo (p<0.001). Superior efficacy was observed across secondary endpoints, including PASI 90, PASI 100, and static Physician’s Global Assessment (sPGA) 0\/1.<\/p>\n Safety Profile:<\/p>\n D-2570 was well-tolerated, with no serious adverse events reported. The majority of adverse events were mild to moderate (CTCAE Grade 1 or 2), and no new safety signals were identified. The safety profile was consistent with other TYK2 inhibitors that are approved or currently in clinical development.<\/p>\n “Moderate to severe plaque psoriasis remains a significant burden for patients, affecting their physical health and quality of life. D-2570 has demonstrated a transformative potential with efficacy approaching that of biologics and IL-23 targeted peptide therapies, while offering the convenience of oral administration,” said Dr. Ling Zhang<\/span>, Chief Medical Officer of InventisBio. “We are committed to advancing the development of D-2570 to bring innovative and effective treatment options to patients living with autoimmune diseases such as psoriasis and inflammatory bowel diseases.”<\/p>\n The complete data from this Phase 2 trial will be presented at upcoming scientific conferences.<\/p>\n About D-2570:<\/p>\n D-2570 is an oral TYK2 JH2 pseudokinase domain inhibitor under development for the treatment of autoimmune diseases, including psoriasis. By selectively targeting TYK2, D-2570 modulates key cytokine signaling pathways involved in autoimmune inflammation, offering a potential alternative to biologic therapies.<\/p>\n About InventisBio:<\/p>\n InventisBio Co., Ltd. is a clinical-stage biotech company dedicated to discovering and developing innovative small-molecule therapies for the treatment of cancer, metabolic and autoimmune diseases. By leveraging a strong research pipeline and a focus on unmet medical needs, InventisBio strives to deliver transformative treatments to patients worldwide.<\/p>\n <\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"rop_custom_images_group":[],"rop_custom_messages_group":[],"rop_publish_now":"initial","rop_publish_now_accounts":[],"rop_publish_now_history":[],"rop_publish_now_status":"pending","footnotes":""},"categories":[5,7],"tags":[],"class_list":["post-14240","post","type-post","status-publish","format-standard","hentry","category-cision-pr-newswire","category-cision-pr-newswire-en"],"_links":{"self":[{"href":"https:\/\/thaipropertynews.com\/feeds\/index.php?rest_route=\/wp\/v2\/posts\/14240","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/thaipropertynews.com\/feeds\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/thaipropertynews.com\/feeds\/index.php?rest_route=\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/thaipropertynews.com\/feeds\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=14240"}],"version-history":[{"count":0,"href":"https:\/\/thaipropertynews.com\/feeds\/index.php?rest_route=\/wp\/v2\/posts\/14240\/revisions"}],"wp:attachment":[{"href":"https:\/\/thaipropertynews.com\/feeds\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=14240"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/thaipropertynews.com\/feeds\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=14240"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/thaipropertynews.com\/feeds\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=14240"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}