{"id":11458,"date":"2025-05-01T09:58:29","date_gmt":"2025-05-01T09:58:29","guid":{"rendered":"https:\/\/www.hotelsalepage.com\/feed\/cision-pr-newswire\/a-global-study-led-by-cuhk-and-the-university-of-calgary-charts-four-stage-evolution-of-inflammatory-bowel-disease\/"},"modified":"2025-05-01T09:58:29","modified_gmt":"2025-05-01T09:58:29","slug":"a-global-study-led-by-cuhk-and-the-university-of-calgary-charts-four-stage-evolution-of-inflammatory-bowel-disease-2","status":"publish","type":"post","link":"https:\/\/thaipropertynews.com\/feeds\/?p=11458","title":{"rendered":"A global study led by CUHK and the University of Calgary charts four-stage evolution of Inflammatory Bowel Disease"},"content":{"rendered":"

HONG KONG<\/span>, May 1, 2025<\/span> \/PRNewswire\/ — An international consortium led by The Chinese University of Hong Kong (CUHK)’s Faculty of Medicine (CU Medicine)\u00a0and the University of Calgary in Canada has conducted\u00a0a global epidemiological study on Inflammatory Bowel Disease (IBD). It found that this chronic gut condition follows a four-stage epidemiological evolution across different regions of the world.\u00a0Analysing data from more than 500 epidemiological studies across 80 regions\u00a0in the past century, the team generated a machine-learning model for classification of stages which enables\u00a0health-care systems to prepare for\u00a0the growing burden on healthcare arising from the prevalence of IBD.\u00a0Results of the study have been published in the leading scientific journal Nature<\/i><\/b><\/a>.<\/b>\u00a0 \u00a0<\/p>\n

\n

\"Professor <\/a>
Professor Gilaad Kaplan (left) and Professor Siew Ng<\/span><\/p>\n<\/div>\n

Epidemiological model informs trend of IBD burden for the next 20 years<\/b> <\/p>\n

The Global IBD Visualization of Epidemiology Studies in the 21st Century (GIVES\u201121) consortium,\u00a0led by Professor Gilaad Kaplan <\/b>of University of Calgary and Professor Siew Ng<\/b> of CU Medicine, synthesised data from 522 population-based studies across 82 geographical regions over the past century. They observed differences in IBD incidence and prevalence across various geographical areas over the past century suggest that epidemiological patterns shift through time.<\/p>\n

To further explore the trends and characterise the epidemiology of IBD independent of geography and time, researchers developed a machine-learning model that classifies regions by epidemiologic stage, maps spatiotemporal transitions across stages and models a theoretical prevalence stage for the next two decades.\u00a0They also demonstrated a stage where IBD prevalence reaches equilibrium. (Please refer to Table 1<\/a>\u00a0for details.)<\/p>\n

Professor Gilaad Kaplan<\/b>, Professor of Medicine at the Cumming School of Medicine, the University of Calgary, said: “Our analysis, drawing on a century’s worth of historical epidemiologic data, enables health authorities to tailor interventions \u2013 whether clinical, policy driven\u00a0or preventive.”\u00a0<\/p>\n

Incidence rapidly rising in China and Malaysia while Japan and South Korea seeing <\/b> an <\/b> acceleration in prevalence <\/b> <\/p>\n

Study data showed epidemiological stages vary among regions in Asia. Japan and South Korea, which underwent rapid industrialisation in the latter half of the 20th<\/sup> century, have reported prevalence exceeding 0.1%, placing them on the brink of transitioning towards stage 3. In contrast, nations like China and Malaysia, which industrialised later, entered stage 2 more recently.<\/p>\n

Dr Joyce Mak,<\/b>\u00a0Honorary Clinical Associate Professor in the Department of Medicine and Therapeutics at CU Medicine, said: “Today, we stand at a critical juncture as we address the alarming rise in IBD in newly industrialised countries such as China and Malaysia. This increase is not just a statistic; it represents the health and well-being of millions of people. As these nations embrace rapid industrialisation and urbanisation, we must prioritise public health initiatives, enhance awareness, and invest in research to understand underlying causes of this disease.”<\/p>\n

Professor Siew Ng<\/b>, Croucher Professor in Medical Sciences at CU Medicine, Director of the Microbiota I-Center (MagIC) and New Cornerstone Investigator, said: “Our GIVES\u201121 consortium is conducting epidemiologic surveillance studies in low- and middle-income countries, as the disease is evolving in these regions. We are seeing a paradigm shift of IBD accelerating in these regions and we will need to prepare our clinical infrastructure and personnel to manage this complex and costly disease. We are planning research to focus on preventive strategies targeting the gut microbiome, diet and environmental exposures to reduce disease incidence.”<\/p>\n

This study was supported by The Leona M. and Harry B. Helmsley Charitable Trust, the International Organization for the study of IBD (IOIBD), and contributions from over 30 international partners.<\/p>","protected":false},"excerpt":{"rendered":"

<\/p>\n

HONG KONG<\/span>, May 1, 2025<\/span> \/PRNewswire\/ — An international consortium led by The Chinese University of Hong Kong (CUHK)’s Faculty of Medicine (CU Medicine)\u00a0and the University of Calgary in Canada has conducted\u00a0a global epidemiological study on Inflammatory Bowel Disease (IBD). It found that this chronic gut condition follows a four-stage epidemiological evolution across different regions of the world.\u00a0Analysing data from more than 500 epidemiological studies across 80 regions\u00a0in the past century, the team generated a machine-learning model for classification of stages which enables\u00a0health-care systems to prepare for\u00a0the growing burden on healthcare arising from the prevalence of IBD.\u00a0Results of the study have been published in the leading scientific journal Nature<\/i><\/b><\/a>.<\/b>\u00a0 \u00a0<\/p>\n

\n

\"Professor <\/a>
Professor Gilaad Kaplan (left) and Professor Siew Ng<\/span><\/p>\n<\/div>\n

Epidemiological model informs trend of IBD burden for the next 20 years<\/b> <\/p>\n

The Global IBD Visualization of Epidemiology Studies in the 21st Century (GIVES\u201121) consortium,\u00a0led by Professor Gilaad Kaplan <\/b>of University of Calgary and Professor Siew Ng<\/b> of CU Medicine, synthesised data from 522 population-based studies across 82 geographical regions over the past century. They observed differences in IBD incidence and prevalence across various geographical areas over the past century suggest that epidemiological patterns shift through time.<\/p>\n

To further explore the trends and characterise the epidemiology of IBD independent of geography and time, researchers developed a machine-learning model that classifies regions by epidemiologic stage, maps spatiotemporal transitions across stages and models a theoretical prevalence stage for the next two decades.\u00a0They also demonstrated a stage where IBD prevalence reaches equilibrium. (Please refer to Table 1<\/a>\u00a0for details.)<\/p>\n

Professor Gilaad Kaplan<\/b>, Professor of Medicine at the Cumming School of Medicine, the University of Calgary, said: “Our analysis, drawing on a century’s worth of historical epidemiologic data, enables health authorities to tailor interventions \u2013 whether clinical, policy driven\u00a0or preventive.”\u00a0<\/p>\n

Incidence rapidly rising in China and Malaysia while Japan and South Korea seeing <\/b> an <\/b> acceleration in prevalence <\/b> <\/p>\n

Study data showed epidemiological stages vary among regions in Asia. Japan and South Korea, which underwent rapid industrialisation in the latter half of the 20th<\/sup> century, have reported prevalence exceeding 0.1%, placing them on the brink of transitioning towards stage 3. In contrast, nations like China and Malaysia, which industrialised later, entered stage 2 more recently.<\/p>\n

Dr Joyce Mak,<\/b>\u00a0Honorary Clinical Associate Professor in the Department of Medicine and Therapeutics at CU Medicine, said: “Today, we stand at a critical juncture as we address the alarming rise in IBD in newly industrialised countries such as China and Malaysia. This increase is not just a statistic; it represents the health and well-being of millions of people. As these nations embrace rapid industrialisation and urbanisation, we must prioritise public health initiatives, enhance awareness, and invest in research to understand underlying causes of this disease.”<\/p>\n

Professor Siew Ng<\/b>, Croucher Professor in Medical Sciences at CU Medicine, Director of the Microbiota I-Center (MagIC) and New Cornerstone Investigator, said: “Our GIVES\u201121 consortium is conducting epidemiologic surveillance studies in low- and middle-income countries, as the disease is evolving in these regions. We are seeing a paradigm shift of IBD accelerating in these regions and we will need to prepare our clinical infrastructure and personnel to manage this complex and costly disease. We are planning research to focus on preventive strategies targeting the gut microbiome, diet and environmental exposures to reduce disease incidence.”<\/p>\n

This study was supported by The Leona M. and Harry B. Helmsley Charitable Trust, the International Organization for the study of IBD (IOIBD), and contributions from over 30 international partners.<\/p>\n

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